Cheesy Cajun Garlic Chicken Rotini Skillet Recipe
Introduction
This Cheesy Cajun Garlic Chicken Rotini Skillet is a creamy, flavorful dish that comes together quickly in one pan. The Cajun seasoning adds a spicy kick while the blend of cheeses creates a rich, comforting sauce perfect for cozy dinners.

Ingredients
- 2 boneless, skinless chicken breasts, cut into bite-sized chunks
- 12 oz rotini pasta
- 2 tablespoons olive oil
- 2 tablespoons Cajun seasoning
- 1 teaspoon garlic powder
- 1/2 teaspoon onion powder
- Salt and pepper, to taste
- 4 cloves garlic, minced
- 1 tablespoon butter
- 1 cup heavy cream
- 1/2 cup chicken broth
- 1 cup shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 1/2 cup shredded cheddar cheese
- Fresh parsley, chopped (for garnish)
Instructions
- Step 1: Bring a large pot of salted water to a boil. Cook the rotini pasta according to the package instructions until al dente. Drain and set aside.
- Step 2: Heat olive oil in a large skillet over medium-high heat. Toss the chicken pieces with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Add the chicken to the skillet and cook for 6 to 7 minutes, until browned and cooked through. Remove the chicken from the skillet and set aside.
- Step 3: In the same skillet, melt the butter. Add the minced garlic and sauté for about 1 minute until fragrant. Pour in the chicken broth and heavy cream, and bring to a gentle simmer.
- Step 4: Stir in the mozzarella, Parmesan, and cheddar cheeses. Mix until the cheese has melted completely and the sauce is smooth.
- Step 5: Return the cooked chicken and drained rotini to the skillet. Toss everything together to coat evenly in the cheesy Cajun garlic sauce. Let it simmer for 2 to 3 minutes to blend the flavors.
- Step 6: Garnish with fresh chopped parsley and extra cheese if desired. Serve hot.
Tips & Variations
- For a lighter version, substitute half-and-half for heavy cream or use reduced-fat cheese.
- Swap chicken breast for shrimp or sausage for a different protein twist.
- Add bell peppers or spinach to the skillet for extra veggies and color.
- If you prefer less spice, reduce the Cajun seasoning or choose a mild blend.
Storage
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop over low heat or in the microwave, adding a splash of milk or broth if the sauce thickens too much.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use a different type of pasta for this dish?
Yes, any short pasta like penne, fusilli, or shells will work well. Just adjust cooking time according to the package instructions.
Is this recipe freezer-friendly?
While you can freeze the cooked chicken and pasta, the creamy sauce may separate upon thawing. It’s best to store leftovers in the refrigerator and consume within a few days for optimal texture and flavor.
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Cheesy Cajun Garlic Chicken Rotini Skillet Recipe
- Total Time: 35 minutes
- Yield: 4 servings 1x
Description
This Cheesy Cajun Garlic Chicken Rotini Skillet is a creamy, cheesy, and flavorful one-pan meal that’s perfect for a comforting dinner. Tender chicken breasts seasoned with Cajun spices are cooked to perfection and combined with al dente rotini pasta in a luscious garlic cream sauce loaded with mozzarella, Parmesan, and cheddar cheeses. Finished with fresh parsley, this dish offers a perfect balance of spice, creaminess, and cheesy goodness, all made effortlessly in one skillet for easy cleanup.
Ingredients
Chicken and Seasonings
- 2 boneless, skinless chicken breasts, cut into bite-sized chunks
- 2 tablespoons olive oil
- 2 tablespoons Cajun seasoning
- 1 teaspoon garlic powder
- 1/2 teaspoon onion powder
- Salt and pepper, to taste
Pasta
- 12 oz rotini pasta
Sauce
- 4 cloves garlic, minced
- 1 tablespoon butter
- 1 cup heavy cream
- 1/2 cup chicken broth
- 1 cup shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 1/2 cup shredded cheddar cheese
Garnish
- Fresh parsley, chopped (for garnish)
Instructions
- Cook the pasta: Bring a large pot of salted water to a boil. Add the rotini pasta and cook according to package instructions until al dente. Drain the pasta and set aside.
- Cook the chicken: Heat olive oil in a large skillet over medium-high heat. Toss the chicken chunks with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Add the seasoned chicken to the skillet and cook for 6 to 7 minutes, stirring occasionally, until browned and fully cooked through. Remove the chicken from the skillet and set aside.
- Make the creamy sauce: In the same skillet, melt the butter over medium heat. Add minced garlic and sauté for about 1 minute until fragrant. Pour in the chicken broth and heavy cream, then bring the mixture to a gentle simmer. Stir in the mozzarella, Parmesan, and cheddar cheeses until they melt smoothly to form a creamy sauce.
- Combine and simmer: Return the cooked rotini and chicken to the skillet. Toss everything together to evenly coat the pasta and chicken in the cheesy Cajun garlic sauce. Let it simmer for 2 to 3 minutes, allowing the flavors to meld together.
- Serve: Garnish with freshly chopped parsley and extra cheese if desired. Serve the dish hot for a comforting and flavorful meal.
Notes
- For a spicier kick, add extra Cajun seasoning or a pinch of cayenne pepper.
- Use freshly grated cheeses for best melting and flavor.
- Leftovers store well in an airtight container in the refrigerator for up to 3 days.
- Reheat gently on the stovetop or microwave with a splash of cream or broth to keep the sauce creamy.
- Gluten-free rotini pasta can be used to make this dish gluten-free.
- Prep Time: 10 minutes
- Cook Time: 25 minutes
- Category: Main Course
- Method: Stovetop
- Cuisine: American
Keywords: cheesy cajun chicken, garlic chicken pasta, rotini skillet, creamy chicken pasta, Cajun chicken recipe, one skillet dinner

